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Proteomic Aging Clocks Track Biological Age Reversal in Rentosertib Trial
Research2w ago

Proteomic Aging Clocks Track Biological Age Reversal in Rentosertib Trial

Researchers from Insilico Medicine and academic collaborators used six proteomic aging clocks to analyze blood samples from a Phase IIa trial of the AI-designed…

#Insilico Medicine#rentosertib#proteomic aging clocks#biotechnology#drug discovery#AI

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1 editorial report · 1 verified social mention. The most authoritative report leads while later evidence completes the story.

Unite.AIPrimary source

Proteomic Aging Clocks Track Biological Age Reversal in Rentosertib Trial

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Social corroboration

telegram1w ago

⚡️An AI-designed drug may have made people biologically younger Rentosertib just delivered a fascinating result: after 12 weeks of treatment, six different biological-age clocks all estimated patients to be roughly 3–4 years younger. The six clocks came from independent groups, used different features and weren’t trained on the same data. Two measure mortality risk, while four track chronological age, yet they still moved in the same direction. • 54 statistical tests. 21 were significant. • By chance, only about 0.15 would be expected. Nobel laureate Michael Levitt says the agreement between the clocks is what caught his attention, while stressing that the study cannot yet prove slower aging, since treating a lung condition could itself change the biomarkers. The next test is Healthy volunteers. If those results hold, things get very interesting. The first experiment is done. Now the race is to see whether AI can actually help us turn back the biological clock. Source. @aipost 🏴

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